{"id":8845,"date":"2026-08-11T09:05:06","date_gmt":"2026-08-11T09:05:06","guid":{"rendered":"https:\/\/majistraleczacilari.org.tr\/?post_type=docs&p=3014"},"modified":"2026-08-21T12:33:39","modified_gmt":"2026-08-21T12:33:39","password":"","slug":"3014","status":"publish","type":"docs","link":"https:\/\/majistraleczacilari.org.tr\/en\/dokumanlar\/hair-formulas\/3014\/","title":{"rendered":""},"content":{"rendered":"
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Diphenylcyclopropenone (DPCP) Treatment in Hair Loss (Alopecia Areata)<\/strong>Diphencyprone (DPCP), also known as diphenylcyclopropenone, is an agent used by some dermatology centers in the treatment of skin diseases via immunotherapy. DPCP is generally used in the treatment of alopecia areata.<\/p>\n

DPCP is applied in the treatment of allergic contact dermatitis and alopecia areata. DPCP is thought to exert its regrowth-promoting effect by preventing autoimmune attacks on hair follicles.<\/p>\n

Although treatment with DPCP has some side effects, in many cases it is tolerable and responds well to treatment.<\/p>\n

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DIPHENYLCYCLOPROPENONE 0.1% TO 2.0% SOLUTIONS<\/strong><\/p>\n

Rp.<\/strong><\/p>\n

Diphenylcyclopropenone 100 mg to 2 g<\/strong><\/p>\n

Acetone                                     qs 100 ml<\/strong><\/p>\n

In clinical practice, initial sensitization is required for DPCP. To test the patient for contact allergy, the clinician applies a high concentration of DPCP (2%) to a small area for 2\u20133 days. The patient or physician then applies a weak concentration of DPCP to the affected areas once a week, using up to 1 ml per session. The solution should remain on the skin for 6\u201324 hours as directed, and then be washed off. Since DPCP is degraded by sunlight, the application area must be kept covered for the first 24 hours. Gloves must be worn by the patient and\/or caregiver during each application. A relative of the patient or a healthcare worker may also develop dermatitis if they come into contact with the medication during application.<\/p>\n

Since DPCP induces contact allergy, local dermatitis is an expected process. A mild reaction with redness and itching is desired and usually lasts 24\u201348 hours.<\/p>\n

In some patients, burning, blistering, or swelling in the treated areas, as well as severe itching, may occur. DPCP is mostly applied to the scalp. It should not be applied over swollen lymph nodes or behind the ears. These side effects usually subside when the treatment is discontinued.<\/p>\n

Once the skin is initially sensitized, a very low concentration of DPCP\u2014for example, 0.001%\u2014is usually selected to reduce the severity of dermatitis. Gradually increasing the concentration over time is the recommended approach; for example, 0.01%, 0.1%, 0.2%, 0.5%, 1%, and 2%.<\/p>\n

Other side effects include:<\/p>\n

– Contact urticaria<\/p>\n

– Generalized autoeczematization<\/p>\n

– Rarely, erythema multiforme-like reaction<\/p>\n

– Hyperpigmentation, hypopigmentation, and vitiligo may be permanent.<\/p>\n

 <\/p>\n

Severe contact reactions and blistering can be treated with potent topical steroids.<\/p>\n

In a retrospective study of 54 patients with alopecia areata, the success rate was found to be 55%.<\/p>\n

DPCP is not effective for everyone. It is recommended to continue treatment for 6 months before declaring treatment failure.<\/p>\n

Scalp treatment can last up to 12 months; in the event of hair regrowth, DPCP treatment is usually continued once weekly. Treatment is discontinued upon hair growth, and the patient is monitored for recurrence. Recurrence rates of 33% in one study and 68.9% in another study on alopecia areata have been reported.<\/p>\n

There are no data on the safety of immunotherapy during pregnancy, and it should not be used in pregnant women or women wishing to become pregnant.<\/p>\n

Other indications for DPCP:<\/p>\n

DPCP may be beneficial in the treatment of recalcitrant verrucae. A center in Melbourne, Australia reported an 88% success rate in palmoplantar warts with 0.1% DPCP and 15% salicylic acid in white soft paraffin. Salicylic acid reduced the accumulation over the warts, thereby facilitating easier skin absorption of DPCP.<\/p>\n

A solution of DPCP in acetone is used. It should be stored in an amber glass bottle away from sunlight and kept in a secure place out of reach of children. The preparation has a shelf life of approximately 6 months.<\/p>\n

Source:<\/strong><\/p>\n

La formulaci\u00f3n magistral en la oficina de farmacia 3. Parte Valencia, 1990<\/p>\n

Exp. Pharm. Ahmet Nezihi Pekcan
\nPekcan Pharmacy – Konya
\npekcanecz@gmail.com
\nTel: (332) 3520657
\nhttp:\/\/www.majistralformul.com\/<\/a><\/p>\n

 <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Diphenylcyclopropenone (DPCP) Treatment in Hair Loss (Alopecia Areata)Diphencyprone (DPCP), also known as diphenylcyclopropenone, is an agent used by some dermatology centers in the treatment of skin diseases via immunotherapy. DPCP […]<\/p>\n","protected":false},"author":1,"featured_media":3015,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_members_access_role":[],"_members_access_error":""},"doc_category":[166],"doc_tag":[],"class_list":["post-8845","docs","type-docs","status-publish","has-post-thumbnail","hentry","doc_category-hair-formulas"],"acf":[],"year_month":"2026-08","word_count":630,"total_views":"2","reactions":{"happy":"0","normal":"0","sad":"0"},"author_info":{"name":"m921a","author_nicename":"m921a","author_url":"https:\/\/majistraleczacilari.org.tr\/en\/author\/m921a\/"},"doc_category_info":[{"term_name":"Hair Formulations","term_url":"https:\/\/majistraleczacilari.org.tr\/en\/dokuman-kategori\/hair-formulas\/"}],"doc_tag_info":[],"knowledge_base_info":[],"knowledge_base_slug":[],"_links":{"self":[{"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/docs\/8845","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/docs"}],"about":[{"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/types\/docs"}],"author":[{"embeddable":true,"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/comments?post=8845"}],"version-history":[{"count":1,"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/docs\/8845\/revisions"}],"predecessor-version":[{"id":8847,"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/docs\/8845\/revisions\/8847"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/media\/3015"}],"wp:attachment":[{"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/media?parent=8845"}],"wp:term":[{"taxonomy":"doc_category","embeddable":true,"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/doc_category?post=8845"},{"taxonomy":"doc_tag","embeddable":true,"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/doc_tag?post=8845"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}