{"id":9003,"date":"2026-08-10T23:26:47","date_gmt":"2026-08-10T23:26:47","guid":{"rendered":"https:\/\/majistraleczacilari.org.tr\/?post_type=docs&#038;p=2299"},"modified":"2026-08-21T11:51:19","modified_gmt":"2026-08-21T11:51:19","password":"","slug":"magistral-formulations-and-pruritus-treatment-new-trends-2","status":"publish","type":"docs","link":"https:\/\/majistraleczacilari.org.tr\/en\/dokumanlar\/antipruritic-anti-inflammatory-astringent-keratolytic-cicatrizing-steroid\/magistral-formulations-and-pruritus-treatment-new-trends-2\/","title":{"rendered":"Magistral Formulations and Pruritus Treatment \u2013 New Trends &#8211; 2"},"content":{"rendered":"<div><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-medium wp-image-2300\" src=\"https:\/\/majistraleczacilari.org.tr\/wp-content\/uploads\/2026\/08\/120_k_1623577839-300x169.jpg\" alt=\"\" width=\"300\" height=\"169\" srcset=\"https:\/\/majistraleczacilari.org.tr\/wp-content\/uploads\/2026\/08\/120_k_1623577839-300x169.jpg 300w, https:\/\/majistraleczacilari.org.tr\/wp-content\/uploads\/2026\/08\/120_k_1623577839.jpg 370w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/div>\n<div><\/div>\n<div><\/div>\n<div class=\"text\">\n<p><strong>Formulations featured in the article (Table 1)<\/strong><\/p>\n<p><strong>Hydrophilic Polihexanide Gel 0.04% \/ 0.1% (NRF 11.131.)<\/strong><\/p>\n<p><strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;0.04%<\/strong><\/p>\n<p><strong>Polihexanide solution concentrate 20% (m\/v) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;0.2 ml<\/strong><\/p>\n<p><strong>Hydroxyethylcellulose 400&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.0 g<\/strong><\/p>\n<p><strong>Water for &nbsp;injections&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;to 100.0 g<\/strong><\/p>\n<p><strong>Substances included in the formula;<\/strong><\/p>\n<p><strong>Polihexanide hydrochloride &#8211; Polyhexamethylene biguanide hydrochloride &#8211; Polihexanide HCl;<\/strong>Polihexanide is a chlorhexidine polymer exhibiting antibacterial and anti-amoebic activity. It is used as a surface disinfectant and in the disinfection of soft contact lenses.<em>Acanthamoeba&nbsp;<\/em>is also used in the treatment of keratitis. It has also been tested in some mouthwash formulations used in dental care.&nbsp; &nbsp;It is primarily used to control the growth of microorganisms, algae, and fungi in swimming pools and spas. It is also used for the disinfection of veterinary products and milking equipment. In general, it is a disinfectant agent used for medical equipment, medical processes, contact lens solutions, surfaces used in food preparation, and in industry.&nbsp;In addition, it is used in the treatment of bacterial vaginosis and infected wounds.<strong>Hyetellose &#8211; Hydroxyethylcellulose &#8211; Hydroxyethylcellulose &#8211; Hydroxyethyl cellulose ;<\/strong>Cellulose 2-hydroxyethyl ether. It has a creamy white powder or fibrous structure. Soluble in cold water, insoluble in hot water. Molar substitution M.S. 25. The viscosity of a 2% solution is 200,000 cP. It is used as a suspending agent and foam stabilizer, film-forming agent, in the food industry, pharmacy, and cosmetics. It is used as a film coating agent, binder, and as a thickening stabilizer and dispersant in shampoo.<strong>Water for injections;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/strong>Water for injections, purified water in the pharmaceutical industry. Intended for medicinal products for parenteral administration where the solvent is water, its quality specifications for parenteral administration are high. Differentiated into &#8220;Water for injections in bulk&#8221; and &#8220;Sterilized water for<strong>Hydrophilic Urea Emulsion 5 % \/ 10 % (NRF&nbsp; 11.72.)<\/strong>It is an emulsion-type preparation applied to hairy areas. It is suitable for dry skin.<strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5 %<\/strong><\/p>\n<p><strong>Urea&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.0 g<\/strong><\/p>\n<p><strong>Lactic acid<\/strong><strong>&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;1.0 g<\/strong><\/p>\n<p><strong>Sodium lactate solution&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;4.0 g<\/strong><\/p>\n<p><strong>Hydrophilic base emulsion DAC &nbsp;&nbsp;&nbsp;to 100.0 g<\/strong><\/p>\n<p><strong>Substances in the formula<\/strong><\/p>\n<p><strong>Harnstoff &#8211; Urea &#8211; Carbamide &#8211; Carbamidum &#8211; Ureia &#8211; Ureum;<\/strong>Urea is used topically in the treatment of psoriasis and in cases where a keratolytic effect is desired. It occurs as transparent to white prismatic crystals or as a white crystalline powder. 1 g dissolves in 1.5 ml of water and 10 ml of alcohol. It is generally used at concentrations of 2\u201320%, and sometimes at higher concentrations. It is also indicated for the treatment of dry skin. On hyperkeratotic skin, it exerts a mild keratolytic effect.<strong>Lactic acid &#8211;<\/strong><strong>Lactic acid &#8211; Milk acid &#8211; Acide lactique &#8211; Lactic acid &#8211;&nbsp;Acidi lactici &#8211; Acide &nbsp;lactique T.K.&nbsp;;<\/strong>Lactic acid is a colorless or light yellow, hygroscopic, odorless liquid with a syrupy consistency and an acidic taste. Lactic acid is miscible with water, alcohol, and ether, and is practically insoluble in chloroform. It is a corrosive poison. Lactic acid is applied topically. Lactic acid should be stored at room temperature below 30\u00b0C in tightly closed, airtight containers. Lactic acid is a substance used in the treatment of skin and vaginal diseases presenting with infection. In dermatology, it is frequently used in combination with salicylic acid for the treatment of warts and corns.<strong>Sodium lactate solution &#8211; Sodium lactate &#8211; Natrii lactas &#8211; Sodium lactate &#8211; Solution de lactate de sodium;<\/strong>Sodium lactate is a colorless or almost colorless, viscous, odorless liquid. It is miscible with water and alcohol. Its solutions are neutral. One gram of anhydrous sodium lactate contains approximately 8.9 mmol of sodium and lactate. 4.88 g of anhydrous sodium lactate is equivalent to approximately 1 g of sodium. Sodium lactate is an alkalinizing agent used parenterally in cases of mild to moderate metabolic acidosis.<strong>Hydrophilic Base Emulsion DAC (NRF S.25.)<\/strong>If we examine this vehicle, which has hydrophilic emulsion properties in the formula;<strong>Sorbitan monostearate&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;2.0 g<\/strong><\/p>\n<p><strong>Macrogol-8 stearate&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;2.0 g<\/strong><\/p>\n<p><strong>Glycerol 85%&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.0 g<\/strong><\/p>\n<p><strong>Medium-chain triglycerides&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.0 g<\/strong><\/p>\n<p><strong>Anhydrous&nbsp; &nbsp;citric acid&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;0.07 g<\/strong><\/p>\n<p><strong>Potassium sorbate&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;0.14 g<\/strong><\/p>\n<p><strong>Purified water&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;to 100.0 g&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<\/strong>To be continued \u2026<\/p>\n<p>Wishing you a good week\u2026<\/p>\n<p>Spec. Pharm. Ahmet Nezihi Pekcan<br \/>\nPekcan Pharmacy &#8211; Konya<br \/>\npekcanecz@gmail.com<\/p>\n<p>Tel: (332) 3520657<\/p>\n<p>Fax: (332) 3512816<em><a href=\"http:\/\/www.majistralformul.com\/\" target=\"_blank\" rel=\"noopener\">http:\/\/www.majistralformul.com\/<\/a><\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Formulations featured in the article (Table 1) Hydrophilic Polihexanide Gel 0.04% \/ 0.1% (NRF 11.131.) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;0.04% Polihexanide solution concentrate 20% (m\/v) &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;0.2 ml Hydroxyethylcellulose 400&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;5.0 g Water for [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2300,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_members_access_role":[],"_members_access_error":""},"doc_category":[146],"doc_tag":[],"class_list":["post-9003","docs","type-docs","status-publish","has-post-thumbnail","hentry","doc_category-antipruritic-anti-inflammatory-astringent-keratolytic-cicatrizing-steroid"],"acf":[],"year_month":"2026-09","word_count":1127,"total_views":"1","reactions":{"happy":"0","normal":"0","sad":"0"},"author_info":{"name":"m921a","author_nicename":"m921a","author_url":"https:\/\/majistraleczacilari.org.tr\/en\/author\/m921a\/"},"doc_category_info":[{"term_name":"Antipruritic - Anti-inflammatory - Astringent - Keratolytic - Cicatrizant - Steroid","term_url":"https:\/\/majistraleczacilari.org.tr\/en\/dokuman-kategori\/antipruritic-anti-inflammatory-astringent-keratolytic-cicatrizing-steroid\/"}],"doc_tag_info":[],"knowledge_base_info":[],"knowledge_base_slug":[],"_links":{"self":[{"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/docs\/9003","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/docs"}],"about":[{"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/types\/docs"}],"author":[{"embeddable":true,"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/comments?post=9003"}],"version-history":[{"count":1,"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/docs\/9003\/revisions"}],"predecessor-version":[{"id":9005,"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/docs\/9003\/revisions\/9005"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/media\/2300"}],"wp:attachment":[{"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/media?parent=9003"}],"wp:term":[{"taxonomy":"doc_category","embeddable":true,"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/doc_category?post=9003"},{"taxonomy":"doc_tag","embeddable":true,"href":"https:\/\/majistraleczacilari.org.tr\/en\/wp-json\/wp\/v2\/doc_tag?post=9003"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}