Dithranol (lipophilic paste 0.10%, 0.25%, 0.50% or 1%)
INDICATIONS
Used in the chronic or subacute topical treatment of psoriasis. In treatment, the concentration is usually increased up to 1% depending on the patient’s tolerance. Here, treatment is initiated with a lipophilic paste containing 0.10% dithranol. As usual, formulation concentrations are increased up to 0.10%, 0.25%, 0.50%, or 1%.
COMPOSITION
Synonyms of the substances in the formula;
Salicylzuur = Salicylic Acid
Triglyceriden met middelmatige ketenlengte = Neutral oil = Medium-chain triglycerides
Zinkoxide = Zinc Oxide
Witte vaseline = White Vaseline / White Petrolatum
METHOD OF PREPARATION
Two mortars are used. The active ingredients are weighed individually.
I – Zinc oxide is levigated in a mortar with a small amount of medium-chain triglycerides (neutral oil). With the addition of a small amount of white petrolatum, it is mixed in the mortar until a homogeneous appearance is obtained.
II – In the second mortar, dithranol and salicylic acid are triturated and softened with the remaining medium-chain triglycerides (neutral oil).
III – The mixtures from both mortars are gradually combined.
IV – White petrolatum is added until the total mass reaches 100 g, and mixing is continued in the mortar until a homogeneous appearance is achieved.
Store at a temperature between 2° C and 8° C.
SHELF LIFE
Two months.
LIMITED SHELF LIFE
Two months.
ANALYTICAL STANDARDS
According to analytical standards, dithranol must be at least 90% and at most 115% of the amount specified in the formula.
COMMENTS
Avoid contact with metal and heat by any means. The 1% salicylic acid included in the formula plays an important role as an inhibitor, preventing the degradation of dithranol by zinc oxide.
Wishing you a good week…
Source: THERAPEUTISCH MAGISTRAAL FORMULARIUM ♦ Uitgave 2010
Spec. Pharm. Ahmet Nezihi Pekcan
Pekcan Pharmacy – Konya
[email protected]
Tel: (332) 3520657
http://www.majistralformul.com/
